SPRAVATO® (esketamine)

What is Spravato™ (Esketamine)?

Spravato™ (esketamine) is the first and only NMDA receptor antagonist approved for the treatment of TRD (Treatment-Resistant Depression) in adults. The FDA has approved Spravato™ (esketamine) nasal spray, in conjunction with an oral antidepressant, for the treatment of depression in adults who have tried other antidepressant medicines but have not benefited from them (treatment-resistant depression). Spravato™ has not been studied as an anesthetic or pain medication and is not approved for use in children or adolescents. The most common side effects experienced by patients treated with Spravato™ are dissociation, dizziness, nausea, sedation, vertigo, decreased feeling or sensitivity (hypoesthesia), anxiety, lethargy, increased blood pressure, vomiting, and feeling drunk. Patients should avoid eating 2 hours prior and drinking 30 minutes prior to the treatment.

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Treatment Schedule

Recommended Dosage for SPRAVATO for Treatment Resistant Depression in Adults

Induction Phase

Weeks 1 to 4:

Day 1 starting dose: 56 mg Administer twice per week

Subsequent doses: 56 mg or 84 mg

Maintenance Phase

Weeks 5 to 8:

Administer once weekly 56 mg or 84 mg

Week 9 and after:

Administer every 2 weeks or once weekly 56 mg or 84 mg

The recommended dosage of SPRAVATO for the treatment of depressive symptoms in adults with Major Depressive Disorder with acute suicidal ideation.

Induction Phase

Weeks 1 to 4:

Starting dose: 84 mg twice per week for 4 weeks.

Dosage may be reduced to 56 mg twice per week based on tolerability.

Maintenance Phase

Weeks 5 to 8:

Administer once weekly 56 mg or 84 mg

Week 9 and after:

Administer every 2 weeks or once weekly 56 mg or 84 mg

What to Expect During Your SPRAVATO® Treatment Video

What to Expect with Treatment

A relaxing, comforting and safe environment is key to a pleasant experience and we’ve been working to perfect it. Patients are provided with warm and weighted blankets, noise-canceling headphones, blindfolds, special music playlists and other items to help enhance the treatment. We are the most experienced treatment facility in the state.

The most commonly observed adverse reactions*

Dissociation
Dizziness
Nausea
Sedation
Vertigo
Hypoesthesia
Anxiety
Lethargy
Blood pressure increased
Vomiting
Feeling drunk

SPRAVATO™ is contraindicated in patients with:

Aneurysmal vascular disease (including thoracic and abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation
History of intracerebral hemorrhage
Hypersensitivity to esketamine, ketamine, or any of the excipients

Insurance Coverage

Our office is happy to verify benefits and provide an estimate of treatment cost with SPRAVATO™. Patients may begin the process by calling our office to initiate care.

Treatment with Spravato™ (esketamine) is typically covered by health insurance but is dependent on insurance approval and plan coverage. Insurance companies established criteria a patient must meet to initiate and continue this treatment. A patient must have depression that is severe and resistant to treatment (failed traditional antidepressants) to meet approval criteria. In addition, patients must demonstrate response to treatment to continue. If patients do not have adequate evidence of symptom improvement or are not compliant with recommendations, insurance companies may not cover continued treatment.

IMPORTANT INFORMATION ABOUT SPRAVATO™

Do not take SPRAVATO™ if you:

have blood vessel (aneurysmal vascular) disease (including in the brain, chest, abdominal aorta, arms and legs)
have an abnormal connection between your veins and arteries (arteriovenous malformation)
have a history of bleeding in the brain
are allergic to esketamine, ketamine, or any of the other ingredients in SPRAVATO™.

If you are not sure if you have any of the above conditions, talk to your healthcare provider before taking SPRAVATO™.

Before you take SPRAVATO™, tell your healthcare provider about all your medical conditions, including if you:

have heart or brain problems, including:

high blood pressure (hypertension)
slow or fast heartbeats that cause shortness of breath, chest pain, lightheadedness, or fainting
history of heart attack
history of stroke
heart valve disease or heart failure
history of brain injury or any condition where there is increased pressure in the brain
have liver problems
have ever had a condition called “psychosis” (see, feel, or hear things that are not there, or believe in things that are not true).
are pregnant or plan to become pregnant. SPRAVATO™ may harm your baby. You should not take SPRAVATO™ if you are pregnant.

Tell your healthcare provider right away if you become pregnant during treatment with SPRAVATO™.

If you can become pregnant, talk to your healthcare provider about methods to prevent pregnancy during treatment with SPRAVATO™. If you are breastfeeding or plan to breastfeed. You should not breastfeed during treatment with SPRAVATO™.

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. Taking SPRAVATO™ with certain medicine may cause side effects. Especially tell your healthcare provider if you take Central Nervous System (CNS) depressants, psychostimulants, or Monoamine oxidase inhibitors (MAOIs) medicines.

How Will I Take SPRAVATO™?

You will take SPRAVATO™ nasal spray yourself, under the supervision of a healthcare provider in a healthcare setting.
Your healthcare provider will show you how to use the SPRAVATO™ nasal spray device.
Your healthcare provider will tell you how much SPRAVATO™ you will take and when you will take it.
Follow your SPRAVATO™ treatment schedule exactly as your healthcare provider tells you to.
During and after each use of the SPRAVATO™ nasal spray device, you will be checked by a healthcare provider who will decide when you are ready to leave the healthcare setting.
You will need to plan for a caregiver or family member to drive you home after taking SPRAVATO™.
If you miss a SPRAVATO™ treatment, your healthcare provider may change your dose and treatment schedule.
Some people taking SPRAVATO™ get nausea and vomiting. You should not eat for at least 2 hours before taking SPRAVATO™ and not drink liquids at least 30 minutes before taking SPRAVATO™.
If you take a nasal corticosteroid or nasal decongestant medicine take these medicines at least 1 hour before taking SPRAVATO™.

What should I avoid while taking SPRAVATO™?
Do not drive, operate machinery, or do anything where you need to be completely alert after taking SPRAVATO™. Do not take part in these activities until the next day following a restful sleep.

What Are the Possible Side Effects of SPRAVATO™?

SPRAVATO™ may cause serious side effects including:

Increased blood pressure. SPRAVATO™ can cause a temporary increase in your blood pressure that may last for about 4 hours after taking a dose. Your healthcare provider will check your blood pressure before taking SPRAVATO™ and for at least 2 hours after you take SPRAVATO™. Tell your healthcare provider right away if you get chest pain, shortness of breath, sudden severe headache, change in vision, or seizures after taking SPRAVATO™.
Problems with thinking clearly. Tell your healthcare provider if you have problems thinking or remembering.
Bladder problems. Tell your healthcare provider if you develop trouble urinating, such as a frequent or urgent need to urinate, pain when urinating, or urinating frequently at night.

The most common side effects of SPRAVATO™ when used along with an antidepressant taken by mouth include dissociation, dizziness, nausea, sedation, spinning sensation, reduced sense of touch and sensation, anxiety, lack of energy, increased blood pressure, vomiting, and feeling drunk.

If these common side effects occur, they usually happen right after taking SPRAVATO™ and go away the same day. These are not all the possible side effects of SPRAVATO™.

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Ketamine Infusions in Wichita

Ketamine Infusions

Ketamine infusions are proving to have astonishing results in relieving symptoms related to many psychiatric conditions such as major depression resistant to traditional therapies, obsessive-compulsive disorders, anxiety, and postpartum depression. Research is also showing ketamine infusions are reducing symptoms related to post traumatic stress disorders (PTSD) and certain chronic pain disorders such as complex regional pain syndrome (CRPS). Watch the videos about how ketamine infusions have changed lives. If you think infusions can help you, call us to schedule an appointment. Ketamine Infusions are offered in Wichita!

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Hydration Therapy

Ketamine Infusions

Dehydration occurs when our bodies lose essential solutions and electrolytes faster than they can be replaced from what we take in by mouth. This can be the result of many factors such as illness, extreme exercise, or even from drinking a little too much the previous night. Rehydration through an intravenous line (IV) can restore electrolytes and fluids faster than taking them orally, especially if vomiting is occurring. Patients who do not require to be hospitalized for their dehydration can have re-hydration services administered in the comfort of our clinic. Re-energize and improve function after a long endurance event such as a marathon, alleviate the dreadful nausea and headache from a hangover, restore electrolytes after being sick from a fever or vomiting; whatever your situation is, call us to schedule an appointment for your hydration therapy. We will get you in rapidly and have you feeling better in no time!

Physicals / Wellness Exams, Minor Disease Treatment

Need to have a comprehensive review of your overall health and wellness that incorporates traditional and holistic therapies? Can’t get to your regular provider for a sport or work physical? Would like to have certain lab work checked? Have a minor condition that you would like to be evaluated for? AIWC can provide all these services with our convenient evening, late, and weekend hours. Call us to schedule an appointment that fits into your schedule. Please note that we do not prescribe opioids or benzodiazepines through any of our wellness or disease management services. We are not providing vaccines at this time.

Migraine Treatment

Physicals / Wellness Exams, Minor Disease Treatment

Lasting a few hours to days, migraine headaches are debilitating and can cause sufferers to lose out on work and family time. Often migraine sufferers have to retreat to dark rooms and bed rest in an attempt to wave off associated symptoms such as nausea, vomiting, and dizziness. Advanced Infusion and is pleased to provide a non-narcotic treatment for chronic migraine suffers who are in active crises. By “numbing up” a special nerve with a local anesthetic that can be accessed through the nasal passage, migraine and chronic headache sufferers can have instant relief. If you are experiencing your typical migraine or chromic headache, give us a call to schedule your appointment to see if this quick, easy treatment relieves your symptoms. (Note: AIWC does not provide emergency services. If this headache is new, different from your typical migraine, or involving a fever, a proper evaluation from your primary care provider or possibly the emergency department is needed. While we attempt to provide migraine suffers with an immediate appointment, AIWC cannot guarantee same day appointments- even though every attempt will be made to see you as soon as possible).

PATIENT FOCUSED INNOVATIVE THERAPIES

SPRAVATO® (esketamine)

What is Spravato™ (Esketamine)?

Ask the Expert

Treatment Schedule

What to Expect with Treatment

Insurance Coverage

IMPORTANT INFORMATION ABOUT SPRAVATO™

How Will I Take SPRAVATO™?

What Are the Possible Side Effects of SPRAVATO™?

Schedule your appointment

Ketamine Infusions in Wichita

Ketamine Infusions

Ketamine Infusions

Ketamine Infusions

Hydration Therapy

Ketamine Infusions

Ketamine Infusions

Physicals / Wellness Exams, Minor Disease Treatment

Physicals / Wellness Exams, Minor Disease Treatment

Physicals / Wellness Exams, Minor Disease Treatment

Migraine Treatment

Physicals / Wellness Exams, Minor Disease Treatment

Physicals / Wellness Exams, Minor Disease Treatment

Tele-Health Services